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4-Octyl itaconate

CAS No. 3133-16-2

4-Octyl itaconate ( 4-Octyl Itaconate; 4 Octyl Itaconate; 4-Octyl-Itaconate )

Catalog No. M18412 CAS No. 3133-16-2

4-Octyl Itaconate is a cell-permeable Itaconate derivative. Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.

Purity : 98%

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

4-Octyl itaconate
Note

Research use only, not for human use.
Brief Description

4-Octyl Itaconate is a cell-permeable Itaconate derivative. Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.
Description

4-Octyl Itaconate is a cell permeable activator of Nrf2 which inhibits LPS-induced increases in IL-1β mRNA, HIF-1α, and IL-10 in macrophages.
Synonyms

4-Octyl Itaconate; 4 Octyl Itaconate; 4-Octyl-Itaconate
Pathway

Others
Target

Other Targets
Recptor

Keap1-Nrf2
Research Area

——
Indication

——

Chemical Information

CAS Number

3133-16-2
Formula Weight

242.31
Molecular Formula

C13H22O4
Purity

98%
Solubility

DMSO : ≥ 150 mg/mL; 619.04 mM
SMILES

CCCCCCCCOC(=O)CC(=C)C(O)=O
Chemical Name

2-Methylene-4-(octyloxy)-4-oxobutanoic acid

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Mills EL, et al. Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1. Nature. 2018 Apr 5;556(7699):113-117.

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