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4-Octyl itaconate

CAS No. 3133-16-2

4-Octyl itaconate ( 4-Octyl Itaconate; 4 Octyl Itaconate; 4-Octyl-Itaconate )

Catalog No. M18412 CAS No. 3133-16-2

4-Octyl Itaconate is a cell-permeable Itaconate derivative. Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.

Purity : 98%

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    4-Octyl itaconate
  • Note
    Research use only, not for human use.
  • Brief Description
    4-Octyl Itaconate is a cell-permeable Itaconate derivative. Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.
  • Description
    4-Octyl Itaconate is a cell permeable activator of Nrf2 which inhibits LPS-induced increases in IL-1β mRNA, HIF-1α, and IL-10 in macrophages.
  • Synonyms
    4-Octyl Itaconate; 4 Octyl Itaconate; 4-Octyl-Itaconate
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Keap1-Nrf2
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    3133-16-2
  • Formula Weight
    242.31
  • Molecular Formula
    C13H22O4
  • Purity
    98%
  • Solubility
    DMSO : ≥ 150 mg/mL; 619.04 mM
  • SMILES
    CCCCCCCCOC(=O)CC(=C)C(O)=O
  • Chemical Name
    2-Methylene-4-(octyloxy)-4-oxobutanoic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Mills EL, et al. Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1. Nature. 2018 Apr 5;556(7699):113-117.
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